CHEM136 Research Review Article
To investigate, understand and communicate about a specific drug – drug target interaction by reading and compiling into a coherent summary at least ten primary research studies. Possible areas to explore include the structure of the target, the structure of the drug, a comparison of the drug and the native substrate, the nature of the drug-target interaction, the mechanism of action, the metabolic process and/or chemical reaction that is interrupted, and the technique and process by which the drug was discovered, such as combinatorial, natural product research, and structure-based drug design.
The paper will be written in the form if a review article (examples will be distributed in class) and will derive from primary research. Primary research studies can include experimental research published in journal articles and patents. Books, reference handbooks, review articles and textbooks may be used to develop a basic understanding, and to discover the primary research studies.
Possible ways to discover possible topics:
Browse journals in the field (see the Library’s Biochemistry page)
Library links need the “ez proxy leader” to work from off-campus. You can add this bookmark:
or paste this in front of your url:
Drug Discovery Today:
Chemical Biology and Drug Design:
Nature Reviews: Drug Discovery (We have 2012 and earlier)
Browse handbooks in the field: (see the Library’s Biochemistry page)
Development of therapeutic agents handbook
(the third section of this book has examples)
Case studies in modern drug discovery and development
Drug discovery handbook
Mandatory Library Workshops
Prior to Week 5: Explore the above resources and your textbook and identify at least 1-3 drug-drug target interactions as possible topics to research.
Prior to Week 9: Complete Research Study File reports for at least 5 primary resources.