3D Structure of Proteins - Sept 18th

Reading (to be completed before class!)

Lehninger 7th ed
Chp 4: 4.3
 
Supplemental Reading
  • Berg Biochemistry
    Chp3: 3.3, 3.4, 3.5 Protein3D Structure

Outcomes:

  1. Know or identify
      • Tertiary and quaternary structure
      • Motif
      • Domain
      • Protein family
      • Disulfide bond
      • Subunit
  2. Identify stabilizing factors in tertiary and quaternary structure
  3. Use Swiss PDB viewer to exam a a-helix
  4. Use Swiss-Pdb Viewer to examine intermolecular interfaces between subunits.

Know from Reading:

  • Fundemental difference between Fibrous proteins and Globular proteins
  • Terms in Bold starting at Structural Diversity Reflects Functional Diversity (p130)
  • Fig 4-18 (motifs), 4-19 (domains), 4-23 (folding patterns)

In Class Activities

3D Structure of Proteins Worksheet

Quaternary Structure Worksheet (essentially tutorial 10 in Deepview)

Problems

  • Lehninger: 7, 9, 13
  • Berg Chp 3 (5th ed): 2, 3, 6, 7, 9
  • Voet: Chp8: 2, 4 (also using Swiss PDBviewer), 18 (also support your answer using SwissPDBviewer), 22  Solutions

- Molecular Modeling wih Swiss PdbViewer
Tutorials 7, 10 , 11 (Try tutorial 10 with 1 HHO.pdb , READ Note!)