Week 13

May 4th - Quinolone Action

Reading

Aldred, K. J., Kerns, R. J. & Osheroff, N. Mechanism of quinolone action and resistance.
Biochemistry 53, 1565–1574 (2014). Get Paper

Problems

Questions from discussion

 

In Class Activity

Please come with questions about the paper. We will compare and record questions and then answer questions as a class. We will also divide into smal groups to address the paper in the context of the writing assignment

 

May 12 - Carbohydrates_Articles

Reading

Read as much as needed to help understand the application in the paper
FRET (quick intro)

Papers
Lamarre-Vincent and Hsieh-Wilson.  Dynamic glycosylation of the transcription factor CREB: A potential role in gene regulation . J Am Chem Soc (2003) vol. 125 (22) pp. 6612-6613

Gross et al.  A strategy to discover inhibitors of O-linked glycosylation . J Am Chem Soc (2008) vol. 130 (2) pp. 440-+

In Class
Leaders for each paper assigned.
FRET paper (Group A - Huma, Sasha, Shane, Kayla, Julian)
CREB paper (Group B - Trevor, Erika, Tessa, Hans, Alina, Amanda)

Each group has 25 minutes to discuss the worksheets regarding their paper
After answering the questions the 2 groups will lead a 15 minute discussion about the article.

CREB worksheet

FRET worksheet