Week 12

April 27 - Membrane Transport Systems


Reading (to be completed before class!)

Required reading and activities
Berg 5th: Chp 13
Intro
Sect 13.1
Sect 13.2
Sect 13.3
Sect 13.4
Sect 13.5
Sect 13.6
Summary

Additional Web Resources

Active Transport

Importins

Multidrug Resistance Transporters (ABC cassette)

Calcium Pump (P-type)

Facilited Diffusion

Potassium Channels

Problems/Questions

Berg Chp 13 5th Ed: 10, 11, 14, 19

Voet TBD

 

 

In Class Activities

Original Group Worksheet

Student altered group worksheet

Worked Problem -  Cell Potential Problem

   

April 29 - ABC transporters

Reading (to be completed before class!)

Review reading

Berg 5th: Chp 13
Intro
Sect 13.3

REQUIRED Reading
Locher et al. Science (2002) vol. 296 (5570) pp. 1091-8
The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism.

Additional Web Resources

Journal of Bioenergetics and Biomembranes
December 2001, Volume 33, Issue 6, pp 453-458
Overview: ABC Transporters and Human Disease

Multidrug Resistance Transporters (ABC cassette)

 

Problems/Questions

TBD

In Class Activities

Finish previous group problem

Original Group Worksheet

Student altered group worksheet

Discuss Research Paper Led by instructor

 

   

May 1 - Drug Targets

Reading

Robertson, J. G. Mechanistic Basis of Enzyme-Targeted Drugs. Biochemistry 44, 5561–5571 (2005). 
Get Paper

Problems

Questions from discussion

 

In Class Activity

Seminar Style Discussion

 

May 8th - Drug Targets

Reading

Robertson, J. G. Mechanistic Basis of Enzyme-Targeted Drugs. Biochemistry 44, 5561–5571 (2005). 
Get Paper

Problems

Questions from discussion

 

In Class Activity

Seminar Style Discussion