Reading (to be completed before class!)
Whitford - Proteins: Structurer and Function: pages 53-58
This is the best prepartion for the worksheet
ON HEAT CAPACITY and HYDROPHOBIC EFFECT
Focus in first two pages
PNAS June 1, 1977 vol. 74 no. 6 2236-2240
We will pay careful attention to the role of thermodynamic principles in governing protein stability.
Weak Forces, Hydrophobic effect, clathrates, free energy changes. This is one of the most important sections since the principles govern protein-substrate and drug interactions, stability of DNA, RNA, and Lipid structures, etc.
Define the hydrophobic effect and explain how it can
Explain the following statement
"The folding process can occur when the combination of the entropy associated with the hydrophobic effect and the enthalpy change associated with hydrogen bonds and van der Waals interactions makes the overall free energy negative."
In Class Activities
- BRING YOUR BOOK or have online reference available in CLASS
Your general chemistry chapter on thermodynamics
Class Summary (please contribute)
- Category: Week 2