Reading (to be completed before class!)

Whitford - Proteins: Structurer and Function: pages 53-58
This is the best prepartion for the worksheet

ON HEAT CAPACITY and HYDROPHOBIC EFFECT
 
Review
Voet 4th ed
Chp 3: all
Chp 8, Sect 4
 
Focus
We will pay careful attention to the role of thermodynamic principles in governing protein stability.
Weak Forces, Hydrophobic effect, clathrates, free energy changes. This is one of the most important sections since the principles govern protein-substrate and drug interactions, stability of DNA, RNA, and Lipid structures, etc.

Problems

Voet Chp 3: 3, 9, 13
Voet Chp 8: 13, 14

Define the hydrophobic effect and explain how it can
influences protein folding?

Additional Review Questions

Explain the following statement

"The folding process can occur when the combination of the entropy associated with the hydrophobic effect and the enthalpy change associated with hydrogen bonds and van der Waals interactions makes the overall free energy negative."

In Class Activities

- BRING YOUR BOOK or have online reference available in CLASS

- Group Problem on Intermolecular forces, thermodynamics, and protein stability - Key

Review

Your general chemistry chapter on thermodynamics

 

Class Summary (please contribute)